Preheat oven to 375 degrees.
Prepare a baking sheet with a silicone mat or parchment paper.
Cube your bread if you haven't already. Add it to a large mixing bowl.
Drizzle the olive oil over the bread and add the Italian seasoning, garlic, onion powder, salt, and pepper to taste.
Toss until bread cubes are coated evenly. Spread cubed bread in a single layer on the baking sheet.
Bake for 10 minutes. Flip croutons. Bake for 10-15 minutes longer until golden and crispy.
Use when fresh for the best flavor. Store in an airtight container on the counter for 3-5 days. Note: the croutons don't stay as crunchy after the first day.